Myrf transcription factor

Author: cgli

August undefined, 2024

WebOct 31, 2013 · Myelin Regulatory Factor (Myrf, also known as Mrf and Gm98) is another transcription factor critically required for CNS myelination [19]. Unlike Sox10, Myrf is not expressed in OPC and becomes expressed only upon cell cycle exit in promyelinating OL. Constitutive Myrf-deficient mice exhibit severe myelination defects. WebSep 24, 2024 · MYRF is a highly conserved gene in eukaryotic organisms ranging from fungi to mammals and a transcriptional regulator that is necessary for oligodendrocyte differentiation and myelin maintenance...

Myrf ER-Bound Transcription Factors Drive - ScienceDirect

WebApr 17, 2024 · The myelin regulatory factor gene (MYRF) encodes a protein evolutionarily conserved from invertebrates to vertebrates, representing a novel type of membrane … WebMYRF (C11orf9, MRF, Ndt80, pqn-47) Protein class i. Disease related genes Human disease related genes Plasma proteins Transcription factors ... This gene encodes a transcription … hudson hi-fi inc

Myocardin-Related Transcription Factor-A Controls …

WebFeb 12, 2024 · Orthologous to human MYRF (myelin regulatory factor). [provided by Alliance of Genome Resources, Apr 2024] Myrf myelin regulatory factor [ (house mouse)] Gene ID: 225908, updated on ... results thus suggest that Fbxw7 controls the transcription of MyRF target genes in various tissues through regulation of MyRF protein stability in a manner ... WebNov 1, 2024 · This particular combination of transcription factors yielded activation rates for each of the regulatory regions that were substantially higher than obtained in parallel transfections for either KLF9 and SOX10 or SOX10 and MYRF (Figure 4J– L). The magnitude of the obtained cooperative effect was impressive for all analysed regulatory regions. WebAug 1, 2013 · The MYRF gene encodes a transcription factor that autoproteolytically cleaves to directly activate myelin genes (Bujalka et al., 2013; Kim et al., 2024) and as such is … hudson highball glass 6 st

Functional mechanisms of MYRF DNA-binding domain …

WebMar 21, 2024 · MYRF: A Mysterious Membrane-Bound Transcription Factor Involved in Myelin Development and Human Diseases. Common Myelin Regulatory Factor Gene Variants Predisposing to Excellence in Sports. The genetic and clinical landscape of nanophthalmos and posterior microphthalmos in an Australian cohort. WebMYRF 11:61752636-61788518 Forward strand gene: myelin regulatory factor Formerly known as: C11orf9 Also known as: MRF, pqn-47, Ndt80, ENSG00000124920 Function: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates … hudson hi fi white acrylic matWebOct 31, 2013 · Myelin Regulatory Factor (Myrf, also known as Mrf and Gm98) is another transcription factor critically required for CNS myelination [19]. Unlike Sox10, Myrf is not … hudson high fi

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Myrf transcription factor

Interactive Repression of MYRF Self-Cleavage and Activity in ...

WebMay 5, 2024 · PAN-1 localizes on cell membrane and binds with MYRF, a membrane-bound transcription factor indispensable for promoting synaptic rewiring. Full-length MYRF was known to undergo self-cleavage on ER membrane and release its transcriptional N-terminal fragment in cultured cells. WebApr 24, 2024 · Myrf-1 and Myrf-2 are homologs of the mammalian Myelin regulatory factor (MYRF) transcription factor, which is required for Myelin development in oligodendrocytes (Emery et al., 2009). In the course of a systematic genetic analysis, the authors surprisingly found that three preexisting myrf-1 alleles, as well as newly generated deletion alleles ...

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WebJun 19, 2024 · MYRF can directly bind putative enhancer sequences of myelin genes, such as Mbp and Plp, to induce their expression [ 5] and together with the transcription factor Sox10, synergistically promote myelin gene expression [ 11, 25 ]. WebApr 24, 2024 · MYRF-1 is a C. elegans ortholog of the recently identified Myrf family ( Emery et al., 2009, Li and Richardson, 2016, Senoo et al., 2012 ). The ju1121 mutation causes a …

WebSep 24, 2024 · Myrf is a pleiotropic membrane-bound transcription factor that plays critical roles in diverse organisms, including in oligodendrocyte differentiation, embryonic … WebNov 14, 2024 · Because MYRF is an ER-associated membrane-bound transcription factor (Bujalka et al., 2013; Li et al., 2013), the physical interaction between TMEM98 and MYRF suggests that TMEM98 is an ER membrane protein as well. To examine this possibility, we expressed mouse TMEM98-3xHA (HA fused at the C terminal), MYRF (589–1138)-3xMYC, …

WebMar 21, 2024 · MYRF (Myelin Regulatory Factor) is a Protein Coding gene. Diseases associated with MYRF include Cardiac-Urogenital Syndrome and … WebA transcription factor is a protein that binds to specific DNA sequences ( enhancer or promoter), either alone or with other proteins in a complex, to control the rate of …

WebJun 16, 2024 · MyRF is the first transcription factor discovered so far in which the DBD forms a homo-trimer by itself. The relative position of the protomer’s DNA binding sites does not allow major structural ...

WebMar 29, 2024 · MYRF. myelin regulatory factor. Gene ID: 745, updated on 29-Mar-2024. Gene type: protein coding. Also known as: MRF; CUGS; MMERV; Ndt80; 11orf9; pqn-47; C11orf9. … hudson hi-fi stylus cleanerWebMyrf is a pleiotropic membrane-bound transcription factor that plays critical roles in diverse organisms, including in oligodendrocyte differentiation, embryonic development, molting, and synaptic plasticity. Upon autolytic cleavage, the Myrf N-terminal fragment enters the nucleus as a homo-trimer and functions as a transcription factor. Homo-trimerization is … hudson highlands ecoregion characterisiticsWebA transcription factor is a protein that binds to specific DNA sequences ( enhancer or promoter), either alone or with other proteins in a complex, to control the rate of transcription of genetic information from DNA to messenger RNA by promoting (serving as an activator) or blocking (serving as a repressor) the recruitment of RNA polymerase. hudson highlands best hikingWebNov 10, 2024 · MYRF-related cardiac urogenital syndrome (MYRF-CUGS) is primarily characterized by anomalies of the internal and external genitalia, congenitalheart defects, and eye anomalies. 46,XY individuals can have a … holding badminton racketWebDec 12, 2024 · Their development is controlled by a network of transcription factors that function as determinants of cell identity or as temporally restricted stage-specific regulators. The continuously expressed Sox10 and Myrf, a factor induced during late development, are particularly important for terminal differentiation. holding badey investissementWebMyrf is a pleiotropic membrane-bound transcription factor that plays critical roles in diverse organisms, including in oligodendrocyte differentiation, embryonic development, molting, … holding baltisseWebAug 1, 2013 · assignment of Myrf as a transcription factor was recently. questioned based on a lack of nuclear localization of the C. elegans. ortholog, pqn-47, with pqn-47 and Myrf instead proposed to have a. hudson high basketball season